Chlorphenesin
valuable
CAS: 104-29-0
EC: 203-192-6
IUPAC: 1,2-Propanediol, 3-(4-chlorophenoxy)-
Updated: August 28, 2023
Descriptions
[GB]Long time ago used as a pharmaceutical muscle relaxant, which works by blocking nerve impulses that are sent to the brain (but nowdays use benzodiazepines which is much safer). In cosmetics, it's used as a preservative because of its anti-fungal and anti-bacterial properties. As a preservative, it prevents various products from running into issues such as viscosity changes, pH changes, emulsion breakdown, visible microorganism growth, color changes and disagreeable odor formation. Secondary to anti-fungal nail treatments, this ingredient is mostly contained in products such as facial moisturizer, anti-aging treatment, sunscreen, foundation, eye cream, cleanser, mascara and concealer.

Safety Measures/Side Effects: Chlorphenesin has been reported to cause irritation and contact dermatitis in many, particularly those with sensitive & dry skin. In addition, research has shown it relax the skeletal muscle, depress the central nervous system and cause respiratory depression (slow or shallow breathing) in infants. Considering this, the FDA dissuades pregnant/nursing women and small children from using personal care products containing this ingredient.

The Panel concluded that chlorphenesin is safe in the present practices of use and concentration.

Chemical data
CAS:
104-29-0
EC:
203-192-6
INN:
chlorophenesin
Ph.Eur. name:
IUPAC:
1,2-Propanediol, 3-(4-chlorophenoxy)-
NOAEL:
LOAEL:
POD:
Smiles:
OCC(O)COc1ccc(Cl)cc1
CosIng synonyms:
paratexin cpe; 1,2-propanediol, 3- (4-chlorophenoxy) -; 3- (4-chlorophenoxy) - 1,2-propanediol; 3- (4-chlorophenoxy) -1,2-propanediol; p-chlorophenyl glyceryl ether; pchlorophenylalphaglyceryl ether (same as chlorphenesin) ; 1,2-propanediol, 3- (4-chlorophenoxy) - (9ci) ; 2-chlorphenesin; 3- (p-chlorophenoxy) -1,2-propanediol; adermykon; demykon; gecophe; (3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate; chlorphenesin carbamate; maolate; musil; adermykon; chlorphenesin; glycerol a-p-chlorophenyl ether; labotest-bb lt01147791; mycil; demykon; gechophen; gecophen; glycerol alpha-p-chlorophenyl ether; klórfenezin
PubChem synonyms:
Safety & Regulation
EU Cosmetic Products Regulation and Amendments
Annex V:
Product type, body part:
MAX Concentration in ready for use preparation:
0.3%
Wording of conditions of use and warnings:
Other:

Products with Chlorphenesin
Product not found!